Maternal deprivation alters expression of neural maturation gene m>tbr1m> in the amygdala paralaminar nucleus in infant female macaques

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• 作者：Danielle M. de Campo ; Judy L. Cameron ; Joseph M. Miano ; David A. Lewis ; Karoly Mirnics and Julie L. Fudge
• 刊名：Developmental Psychobiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：59
• 期：2
• 页码：235-249
• 全文大小：2124K
• ISSN：1098-2302

文摘

Early parental loss is associated with social–emotional dysregulation and amygdala physiologic changes. Previously, we examined whole amygdala gene expression in infant monkeys exposed to early maternal deprivation. Here, we focus on an amygdala region with immature neurons at birth: the paralaminar nucleus (PL). We hypothesized that 1) the normal infant PL is enriched in a subset of neural maturation (NM) genes compared to a nearby amygdala subregion; and 2) maternal deprivation would downregulate expression of NM transcripts (mRNA). mRNAs for m>bcl2, doublecortinm>, m>neuroD1m>, and m>tbr1m>—genes expressed in post-mitotic neurons—were enriched in the normal PL. Maternal deprivation at either 1 week or 1 month of age resulted in PL-specific downregulation of m>tbr1m>—a transcription factor necessary for directing neuroblasts to a glutamatergic phenotype. m>tbr1m> expression also correlated with typical social behaviors. We conclude that maternal deprivation influences glutamatergic neuronal development in the PL, possibly influencing circuits mediating social learning.