Copper Catalysis in Living Systems and In Situ Drug Synthesis
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- 作者：Jessica Clavadetscher ; Scott Hoffmann ; Dr. Annamaria Lilienkampf ; Dr. Logan Mackay ; Dr. Rahimi M. Yusop ; Dr. Sebastien A. Rider ; Prof. John J. Mullins and Prof. Dr. Mark Bradley
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：December 12, 2016
- 年：2016
- 卷：55
- 期：50
- 页码：15662-15666
- 全文大小：2996K
- ISSN：1521-3773
文摘
The copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction has proven to be a pivotal advance in chemical ligation strategies with applications ranging from polymer fabrication to bioconjugation. However, application in vivo has been limited by the inherent toxicity of the copper catalyst. Herein, we report the application of heterogeneous copper catalysts in azide–alkyne cycloaddition processes in biological systems ranging from cells to zebrafish, with reactions spanning from fluorophore activation to the first reported in situ generation of a triazole-containing anticancer agent from two benign components, opening up many new avenues of exploration for CuAAC chemistry.