Combination of phosphotidylinositol-3-kinase targeting with cetuximab and irradiation: A preclinical study on an orthotopic xenograft model of head and neck cancer
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- 作者：Alexandre Bozec ; Nathalie Ebran ; Nina Radosevic-Robin ; Emmanuel Chamorey ; Hedi Ben Yahia ; Serge Marcie ; Mathieu Gautier ; Fré ; dé ; rique Penault-Llorca and Gé ; rard Milano
- 刊名：Head & Neck
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：39
- 期：1
- 页码：151-159
- 全文大小：516K
- ISSN：1097-0347
文摘
The purpose of this study was to investigate the effects of combining the phosphotidylinositol-3-kinase (PI3K) inhibitor buparlisib (BKM)120 with the anti-epidermal growth factor receptor (EGFR) agent cetuximab and radiotherapy (RT) on an orthotopic model of head and neck squamous cell carcinoma (HNSCC).