Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts
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- 作者：Thomas Martzel ; Jean-Franç ; ois Lohier ; Annie-Claude Gaumont ; Jean-Franç ; ois Briè ; re and Sté ; phane Perrio
- 刊名：Advanced Synthesis & Catalysis
- 出版年：2017
- 出版时间：January 4, 2017
- 年：2017
- 卷：359
- 期：1
- 页码：96-106
- 全文大小：1720K
- ISSN：1615-4169
文摘
The efficient sulfinate-catalyzed intermolecular addition reaction of α-substituted allenyl sulfones and allenoates with Michael acceptors is highlighted. The sequence proceeds under mild conditions to provide a scalable and efficient access to versatile functionalized alkynes, displaying a quaternary stereocentre at the propargylic position. This work enriches the diversity of Lewis base organocatalysts in the field of allene chemistry, in addition to the well-established phosphine and amine catalysts.