Inside Back Cover: Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules (ChemBioChem 1/2017)
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- 作者：Dr. Aurora Sganappa ; Dr. Ezequiel Wexselblatt ; Dr. Maria Cristina Bellucci ; Prof. Dr. Jeffrey D. Esko ; Prof. Dr. Gabriella Tedeschi ; Prof. Dr. Yitzhak Tor and Prof. Dr. Alessandro Volonterio
- 刊名：ChemBioChem
- 出版年：2017
- 出版时间：January 3, 2017
- 年：2017
- 卷：18
- 期：1
- 页码：150
- 全文大小：1914K
- ISSN：1439-7633
文摘
The inside back cover picture shows the ability of dendrimeric amino- and, in a much more efficient way, guanidinoneomycin-PAMAM vehicles to promote the cellular uptake of high-molecular-weight biologicals, such as enzymes or proteins. These conjugates have been synthetized by tethering neomycin and guanidinoneomycin to PAMAM dendrimers of generations 2 and 4 through isothiocyanate-amine click chemistry. The mechanism of entry depends on the presence of heparan sulfate proteoglycans on the cell surface, as no uptake has been observed in mutant cells lacking heparan sulfate. Stefano Pirola is acknowledged for the graphic design of the cover. More information can be found in the full paper by Y. Tor, A. Volonterio et al. on page 119 in Issue 1, 2017 (DOI: 10.1002/cbic.201600422).