Surface Charge Convertible and Biodegradable Synthetic Zwitterionic Nanoparticles for Enhancing Cellular Drug Uptake

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• 作者：Luyan Wu ; Caihua Ni ; Liping Zhang ; Gang Shi ; Xue Bai ; Yamin Zhou and Fei He
• 关键词：biodegradable nanoparticles ; cellular uptake ; drug delivery ; redox sensitive ; zwitterions
• 刊名：Macromolecular Bioscience
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：16
• 期：3
• 页码：308-313
• 全文大小：1240K
• ISSN：1616-5195

文摘

To enhance drug cellular uptake, a biodegradable terpolymer is synthesized using taurine, N,N-Bis (acryloyl) cystamine, and dodecylamine as raw materials by Michael addition terpolymerization. The terpolymer is transformed to zwitterionic nanoparticles (NPs) through self-assembly. The surface charge of the NPs is convertible from negative at pH 7.4 to positive at pH 6.5, which endows the NPs’ excellent nonfouling feature in bloodstream and effective uptake in tumor cells. The NPs display varied morphologies from solid micelles to polymersomes and nanorods depending on molar ratios of the structural units involved. The NPs can be biodegraded in l-glutathione (GSH) solution due to the split of disulfide bonds in main chains of the terpolymers. The NPs demonstrate good pH/reducing responsiveness in drug delivery and can be potentially used as anticancer drug vehicles for enhancement of cellular uptake of anticancer drug.