Polymorphisms of the TCF4 gene are associated with the risk of schizophrenia in the Han Chinese

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• 作者：Jingjie Li ; Zhengshuai Chen ; Fengjiao Wang ; Yongri Ouyang ; Ning Zhang ; Min Yang ; Mengdan Yan ; Xikai Zhu ; Xue He ; Dongya Yuan and Tianbo Jin
• 刊名：American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：171
• 期：8
• 页码：1006-1012
• 全文大小：182K
• ISSN：1552-485X

文摘

Schizophrenia (SCZ) is a complex and severe mental disorder with highly heritability (80%). Several large genome-wide association studies have identified that the transcription factor 4 (TCF4) polymorphisms were strongly associated with SCZ. Therefore, the present study was to replicate the potential relationships between the TCF4 polymorphisms and SCZ. Furthermore, the study also investigated whether other variants were associated with SCZ in the Han Chinese. We conducted a case-control study including 499 patients and 500 healthy controls. Five SNPs were successfully genotyped and evaluated the association with SCZ by using χ² test and genetic model analysis. We found that the genotype “AG” of rs9320010 and “GA” of rs7235757 decreased SCZ risk (OR = 0.70, 95%CI = 0.50–0.99, P = 0.041; OR = 0.69, 95%CI = 0.49–0.97, P = 0.034, respectively). In the genetic model analysis, we also observed that the allele “A” of rs9320010 and “G” of rs7235757 were inversely related with the risk of SCZ in the dominant model (OR = 0.72, 95%CI = 0.52–0.98, P = 0.039; OR = 0.69, 95%CI = 0.50–0.96, P = 0.025, respectively). Further interaction and stratification analysis suggested that rs1452787 was notably correlated with increased SCZ risk in males (OR = 2.77, 95%CI = 1.43–5.35, P = 0.002). Our study indicated that rs9320010, rs7235757, and rs1452787 were prominently associated with SCZ. Further studies are required to verify our findings and focus on determining the biological functions of the SNPs.