Co-targeting of multiple microRNAs on factor-Inhibiting hypoxia-Inducible factor gene for the pathogenesis of head and neck carcinomas

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• 作者：Shou-Yen Kao ; Meng-Miao Tsai ; Cheng-Hsieh Wu ; Jing-Jung Chen ; Ssu-Hsueh Tseng ; Shu-Chun Lin and Kuo-Wei Chang
• 关键词：factor-inhibiting hypoxia (FIH) ; head and neck squamous cell carcinoma (HNSCC) ; microRNAs (miRNAs) miR-21 ; miR-31 ; miR-184
• 刊名：Head & Neck
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：38
• 期：4
• 页码：522-528
• 全文大小：346K
• ISSN：1097-0347

文摘

MicroRNAs (miRNAs) are short, noncoding RNAs that inhibit the expression of target genes that play roles in tumorigenesis. MiR-21, miR-31, and miR-184 are oncogenic miRNAs for head and neck squamous cell carcinoma (HNSCC). Factor-inhibiting hypoxia (FIH)-inducible factor is known to inactivate hypoxia-induced downstream effectors and is involved in HNSCC suppression. This study investigates whether miR-21, miR-31, and miR-184 target FIH in HNSCC.