DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies
详细信息 查看全文
- 作者：Yu Funahashi ; Yuta Yoshino ; Kiyohiro Yamazaki ; Yoko Mori ; Takaaki Mori ; Yuki Ozaki ; Tomoko Sao ; Shinichiro Ochi ; Jun-ichi Iga and Shu-ichi Ueno
- 刊名：Psychiatry and Clinical Neurosciences
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：71
- 期：1
- 页码：28-35
- 全文大小：427K
- ISSN：1440-1819
文摘
It is difficult to diagnose dementia with Lewy bodies (DLB) because it exhibits clinical and neuropathological overlap with both Alzheimer's disease and Parkinson's disease. The α-synuclein protein is a major component of Lewy bodies, and accumulation of α-synuclein aggregates causes synaptic dysfunction in DLB. Epigenetic changes at the synuclein alpha ( SNCA ) gene may be involved in DLB pathogenesis.