Enaminones as Synthons for a Directed C−H Functionalization: RhIII-Catalyzed Synthesis of Naphthalenes

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• 作者：Shuguang Zhou ; Jinhu Wang ; Lili Wang ; Chao Song ; Kehao Chen and Prof. Dr. Jin Zhu
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：August 1, 2016
• 年：2016
• 卷：128
• 期：32
• 页码：9530-9534
• 全文大小：904K
• ISSN：1521-3757

文摘

The use of enaminones as effective synthons for a directed C−H functionalization is reported. Proof-of-concept protocols have been developed for the Rh^III-catalyzed synthesis of naphthalenes, based on the coupling of enaminones with either alkynes or α-diazo-β-ketoesters. Two inherently reactive functionalities (hydroxy and aldehyde groups) are integrated into the newly formed cyclic framework and a broad range of substituents are tolerated, rendering target products readily available for further elaboration.