Carbonylation of Anthranilic Acid with Aryl and Heteroaryl Bromides to Synthesize Benzoxazinone Derivatives
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- 作者：Sujit P. Chavan and Prof. Bhalchandra M. Bhanage
- 刊名：Asian Journal of Organic Chemistry
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：5
- 期：9
- 页码：1120-1123
- 全文大小：597K
- ISSN：2193-5815
文摘
A simple and efficient, PdCl<sub>2sub>(PhCN)<sub>2sub>/P(tBu)<sub>3sub>⋅HBF<sub>4sub>-catalyzed carbonylative cyclization of anthranilic acid with aryl bromide was investigated for the synthesis of benzoxazinones under mild reaction conditions. The developed protocol has been extended for the synthesis of quinazolin-4(3 H)-ones. Furthermore, the tolerance of a wide range of functional groups on anthranilic acid as well as on aryl bromide demonstrates the practical utility of the protocol.