Do K_V7.1 channels contribute to control of arterial vascular tone?

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• 作者：Dmitry Tsvetkov ; Mario Kaß ; mann ; Jean-Yves Tano ; Lan Chen ; Johanna Schleifenbaum ; Jakob Voelkl ; Florian Lang ; Yu Huang and Maik Gollasch
• 刊名：British Journal of Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：174
• 期：2
• 页码：150-162
• 全文大小：1737K
• ISSN：1476-5381

文摘

K_V7.1 voltage-gated potassium channels are expressed in vascular smooth muscle cells (VSMC) of diverse arteries, including mesenteric arteries. Based on pharmacological evidence using R-L3 (K_V7.1 channel opener), HMR1556, chromanol 293B (K_V7.1 channel blockers), stimulation of these channels has been suggested to evoke profound relaxation in various vascular beds of rats. However, the specificity of these drugs in vivo is uncertain.