Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy

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• 作者：Chengjun Chen ; Shukun Li ; Kai Liu ; Guanghui Ma and Xuehai Yan
• 刊名：Small
• 出版年：2016
• 出版时间：September 14, 2016
• 年：2016
• 卷：12
• 期：34
• 页码：4719-4725
• 全文大小：1787K
• ISSN：1613-6829

文摘

Biomimetic delivery carriers using polypeptide/heparin hybrid nanoparticles that are adsorbed onto red blood cells for extended blood circulation time have been developed. This might open up an avenue to promote the innovations and advances of biomimetic, stimuli-responsive drug delivery, especially for the site-specific treatment of intravascular diseases such as thrombosis.