Combined ultrasound-targeted microbubble destruction and polyethylenimine-mediated plasmid DNA delivery to the rat retina: enhanced efficiency and accelerated expression

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• 作者：Hongli Li ; Jin Qian ; Chunfang Yao ; Caifeng Wan and Fenghua Li
• 刊名：The Journal of Gene Medicine
• 出版年：2016
• 出版时间：April-June 2016
• 年：2016
• 卷：18
• 期：4-6
• 页码：47-56
• 全文大小：291K
• ISSN：1521-2254

文摘

Gene therapy has potential in the treatment of refractory retinal diseases. It is important to develop an effective delivery system in the retina. The present study aimed to investigate the efficacy and safety of ultrasound (US)-targeted microbubble destruction (UTMD)-mediated polyethylenimine (PEI) to the rat retina.