A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals

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• 作者：Mirong Guan ; Jie Li ; Qingyan Jia ; Jiechao Ge ; Daiqin Chen ; Yue Zhou ; Pengfei Wang ; Toujun Zou ; Mingming Zhen ; Chunru Wang and Chunying Shu
• 刊名：Advanced Healthcare Materials
• 出版年：2016
• 出版时间：September 7, 2016
• 年：2016
• 卷：5
• 期：17
• 页码：2283-2294
• 全文大小：3521K
• ISSN：2192-2659

文摘

Nanocarbons such as carbon nanotubes, graphene derivatives, and carbon nanohorns have illustrated their potential uses as cancer theranostics owing to their intrinsic fluorescence or NIR absorbance as well as superior cargo loading capacity. However, some problems still need to be addressed, such as the fates and long-term toxicology of different nanocarbons in vivo and the improvement of their performance in various biomedical imaging-guided cancer therapy systems. Herein, a versatile and clearable nanocarbon theranostic based on carbon dots (CDs) and gadolinium metallofullerene nanocrystals (GFNCs) is first developed, in which GFNCs enhance the tumor accumulation of CDs, and CDs enhance the relaxivity of GFNCs, leading to an efficient multimodal imaging-guided photodynamic therapy in vivo without obvious long-term toxicity. Furthermore, biochemical analysis reveals that the novel nanotheranostic can harmlessly eliminate from the body in a reasonable period of time after exerting diagnostic and therapeutic function.