Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients

详细信息    查看全文

• 作者：Nithin D. Adappa ; Carl M. Truesdale ; Alan D. Workman ; Laurel Doghramji ; Corrine Mansfield ; David W. Kennedy ; James N. Palmer ; Beverly J. Cowart and Noam A. Cohen
• 刊名：International Forum of Allergy & Rhinology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：6
• 期：8
• 页码：783-791
• 全文大小：536K
• ISSN：2042-6984

文摘

Sinonasal biofilms have been demonstrated in specimens collected from chronic rhinosinusitis (CRS) patients. Mounting evidence suggests that biofilms contribute to therapeutically recalcitrant CRS. Recently, the bitter taste receptor T2R38 has been implicated in the regulation of the sinonasal mucosal innate immune response. TAS2R38 gene polymorphisms affect receptor functionality and contribute to variations seen in sinonasal innate defense as well as taste perception reflected in gustatory sensitivity to the bitter compound phenylthiocarbamide (PTC). In a population of CRS patients with active infection or inflammation, we sought to determine if a correlation between T2R38 phenotype and in vitro biofilm formation existed.