HLA-DPB1 as a Risk Factor for Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Cohort Study

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• 作者：Marc Hilhorst ; Fabian Arndt ; Michael Joseph Kemna ; Stefan Wieczorek ; Yoni Donner ; Benjamin Wilde ; Jö ; rg Thomas Epplen ; Pieter van Paassen and Jan Willem Cohen Tervaert
• 刊名：Arthritis & Rheumatism
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：68
• 期：7
• 页码：1721-1730
• 全文大小：280K
• ISSN：1529-0131

文摘

The antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAVs) form a group of small-vessel vasculitides with systemic involvement. Although the etiology of AAVs remains largely unknown, both genetic and environmental factors have been implicated. Recently, certain alleles in the HLA–DPB1 region on chromosome 6 were shown to be associated with proteinase 3 (PR3)–ANCA–positive AAV but not with myeloperoxidase (MPO)–ANCA–positive AAV. The aim of this study was to investigate whether different alleles in the HLA–DPB1 region have clinical and/or prognostic implications in AAV.