Early infiltration of p40IL12+CCR7+CD11b+ cells is critical for fibrosis development
详细信息 查看全文
- 作者：Tarcio Teodoro Braga ; Matheus Correa-Costa ; Hatylas Azevedo ; Reinaldo Correia Silva ; Mario Costa Cruz ; Maira Estanislau Soares Almeida ; Meire Ioshie Hiyane ; Carlos Alberto Moreira-Filho ; Marinilce Fagundes Santos ; Katia Regina Perez ; Iolanda Midea Cuccovia and Niels Olsen Saraiva Camara
- 刊名：Immunity, Inflammation and Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：4
- 期：3
- 页码：300-314
- 全文大小：1612K
- ISSN：2050-4527
文摘
Macrophages are heterogeneous and thus can be correlated with distinct tissue outcomes after injury. Conflicting data have indicated that the M2-related phenotype directly triggers fibrosis. Conversely, we hypothesize here that the inflammatory milieu provided by early infiltration of pro-inflammatory macrophages dictates tissue scarring after injury.