文摘
Oxygen-containing heterocycles are an important class of compounds with diverse biological activities. In recent years, direct α-C–H functionalization of inexpensive and abundant readily available ethers and alcohols by oxidative radical cross-coupling with different nucleophilic partners (C–H, N–H, O–H and S–S), leading to the construction of C–C and C–X (X=C, N, O, S) bonds, has emerged as one of the vital strategies among oxidative cross-coupling reactions. Owing to the features of being atom-economic, environmentally benign, having a simple operation and biologically properties, a series of ether α-C(sp3)–H bond activation reactions have been developed by metal or metal-free systems via the radical oxidative coupling pathway, since the radical oxidative coupling reactions have wide range of applications. This review aims to highlight the recent advances in direct α-C(sp3)–H bond functionalization of ethers and alcohols via radical oxidative process.