Recent Advances of Oxidative Radical Cross-Coupling Reactions: Direct α-C(sp³)-H Bond Functionalization of Ethers and Alcohols

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• 作者：Sheng-rong Guo ; Pailla Santhosh Kumar and Minghua Yang
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：January 4, 2017
• 年：2017
• 卷：359
• 期：1
• 页码：2-25
• 全文大小：4576K
• ISSN：1615-4169

文摘

Oxygen-containing heterocycles are an important class of compounds with diverse biological activities. In recent years, direct α-C–H functionalization of inexpensive and abundant readily available ethers and alcohols by oxidative radical cross-coupling with different nucleophilic partners (C–H, N–H, O–H and S–S), leading to the construction of C–C and C–X (X=C, N, O, S) bonds, has emerged as one of the vital strategies among oxidative cross-coupling reactions. Owing to the features of being atom-economic, environmentally benign, having a simple operation and biologically properties, a series of ether α-C(sp³)–H bond activation reactions have been developed by metal or metal-free systems via the radical oxidative coupling pathway, since the radical oxidative coupling reactions have wide range of applications. This review aims to highlight the recent advances in direct α-C(sp³)–H bond functionalization of ethers and alcohols via radical oxidative process.