Secretome analysis of human articular chondrocytes unravels catabolic effects of nicotine on the joint
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- 作者：Lucí ; a Lourido ; Valentina Calamia ; Patricia Ferná ; ndez-Puente ; Jesú ; s Mateos ; Natividad Oreiro ; Francisco J. Blanco and Cristina Ruiz-Romero
- 刊名：PROTEOMICS - Clinical Applications
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：10
- 期：6
- 页码：671-680
- 全文大小：416K
- ISSN：1862-8354
文摘
Osteoarthritis (OA) is a degenerative joint pathology characterized by articular cartilage degradation that lacks from efficient therapy. Since previous epidemiological data show a high controversy regarding the role of smoking in OA, we aimed to evaluate the effects of nicotine (the most physiologically active compound of tobacco) on the joint.