The front cover image, provided by Giovanni Di Mauro,
Daniel Kaiser and Nuno Maulide, illustrates the conversion of vinyl cations, as high-energy intermediates, into systems prone to charge-accelerated Claisen-type [3,3]-sigmatropic rearrangements. Starting from simple precurs
ors, vinyl cation f
ormation enables a rapid increase of molecular complexity, aff
ording α-arylated carbonyl compounds that can be easily elab
orated into drug-like scaffolds. The setting to this cascade of reactions is provided by the famous (and beautiful) Karlskirche in Vienna (Foto: G. Kücükkaplan). Further details can be found in the full paper on page 64–77 (D. Kaiser, L. F. Veiros, N. Maulide,
Adv. Synth. Catal.
2017,
359, 64–77; DOI:
org/10.1002/adsc.201600860" rel="references:https://doi.org/10.1002/adsc.201600860">10.1002/adsc.201600860)