Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity

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• 作者：William W. Carroll ; Brendan P. O' ; Connell ; Rodney J. Schlosser ; David A. Gudis ; Tom T. Karnezis ; Lauren A. Lawrence ; Zachary M. Soler and Jennifer K. Mulligan
• 关键词：chronic rhinosinusitis ; endoscopic sinus surgery ; SNOT-22 ; quality of life ; sinusitis
• 刊名：International Forum of Allergy & Rhinology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：6
• 期：2
• 页码：162-168
• 全文大小：559K
• ISSN：2042-6984

文摘

Fibroblasts are implicated in tissue remodeling and recruitment of inflammatory cells in chronic rhinosinusitis (CRS). Populations of fibroblasts remain unquantified in CRS subtypes. The objectives of this study were to measure fibroblast populations in subtypes of CRS, and to investigate the association between fibroblasts and disease severity.