The utility of m>ETV1, ETV4m> and m>ETV5 m>RNA m>in-situm> hybridization in the diagnosis of m>CIC-DUXm> sarcomas

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• 作者：Steven C Smith ; Nallasivam Palanisamy ; Elizabeth Martin ; Jorge Almenara ; Jonathan B McHugh ; Eun-Young K Choi ; David R Lucas ; Bryan L Betz ; Dafydd Thomas and Rajiv M Patel
• 刊名：Histopathology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：70
• 期：4
• 页码：657-663
• 全文大小：4530K
• ISSN：1365-2559

文摘

A recently characterized group of undifferentiated small round cell sarcomas harbours fusions of the genes m>CICm> and m>DUX4m>. Studies report a distinctive gene expression profile for these sarcomas, including expression of E26 transformation-specific (ETS) family proto-oncogenic transcription factors m>ETV1, ETV4m> and m>ETV5m>. To test the utility of an ancillary diagnostic technique for these tumours, we evaluated chromogenic RNA m>in-situm> hybridization assays for m>ETV1m>,m> ETV4m> and m>ETV5m> as diagnostic adjuncts for this emerging group of highly malignant sarcomas.