The ANK3 gene and facial affect processing: An ERP study
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- 作者：Wan Zhao ; Qiumei Zhang ; Ping Yu ; Zhifang Zhang ; Xiongying Chen ; Huang Gu ; Jinguo Zhai ; Min Chen ; Boqi Du ; Xiaoxiang Deng ; Feng Ji ; Chuanyue Wang ; Yu-Tao Xiang ; Dawei Li ; Hongjie Wu ; Qi Dong ; Yuejia Luo ; Jun Li and Chuansheng Chen
- 刊名：American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：171
- 期：6
- 页码：861-866
- 全文大小：183K
- ISSN：1552-485X
文摘
ANK3 is one of the most promising candidate genes for bipolar disorder (BD). A polymorphism (rs10994336) within the ANK3 gene has been associated with BD in at least three genome-wide association studies of BD [McGuffin et al., 2003; Kieseppä, 2004; Edvardsen et al., 2008]. Because facial affect processing is disrupted in patients with BD, the current study aimed to explore whether the BD risk alleles are associated with the N170, an early event-related potential (ERP) component related to facial affect processing. We collected data from two independent samples of healthy individuals (Ns = 83 and 82, respectively) to test the association between rs10994336 and an early event-related potential (ERP) component (N170) that is sensitive to facial affect processing. Repeated-measures analysis of covariance in both samples consistently revealed significant main effects of rs10994336 genotype (Sample I: F (1, 72) = 7.24, P = 0.009; Sample II: F (1, 69) = 11.81, P = 0.001), but no significant interaction of genotype × electrodes (Ps > 0.05) or genotype × emotional conditions (Ps > 0.05). These results suggested that rs10994336 was linked to early ERP component reflecting facial structural encoding during facial affect processing. These results shed new light on the brain mechanism of this risk SNP and associated disorders such as BD.