Highly Efficient Brønsted Acidic Ionic Liquid Promoted Direct Diazenylation of Pyrazolones with Aryltriazenes under Mild Conditions
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- 作者：Dr. Yonghong Zhang ; Haiyan Hu ; Prof. Dr. Chen-Jiang Liu ; Dawei Cao ; Bin Wang ; Dr. Yadong Sun and Dr. Ablimit Abdukader
- 刊名：Asian Journal of Organic Chemistry
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：6
- 期：1
- 页码：102-107
- 全文大小：1548K
- ISSN：2193-5815
文摘
We report the first Brønsted acidic ionic liquid (IL) promoted reaction of 5-pyrazolones with aryltriazenes to prepare arylazopyrazolones. The reaction was carried out with the aryltriazenes as diazotizing agents, water as the solvent, and the ionic liquid as the promoter at room temperature under air and metal-free conditions. The desired products were obtained in good to excellent yields. Notably, a gram-scale experiment and a late-stage diazenylation reaction of a pharmaceutical derivative also furnished the desired products under mild conditions.