ChemInform Abstract: Diastereodivergent Asymmetric Michael Addition of Cyclic Azomethine Ylides to Nitroalkenes: Direct Approach for the Synthesis of 1,7-Diazaspiro[4.4]nonane Diastereoisomers.
A highly diastereoselective and enantioselective catalytic Michael addition of cyclic azomethine ylides with nitro alkenes selectively affords either the syn or anti Michael adducts depending on the ligand used in the copper catalytic system.