Design and Photophysical Studies of Acridine-Based Ru^II Complexes for Applications as DNA Photoprobes

详细信息    查看全文

• 作者：Quentin Deraedt ; Lionel Marcé ; lis ; Thomas Auvray ; Garry S. Hanan ; Fré ; dé ; rique Loiseau and Benjamin Elias
• 刊名：European Journal of Inorganic Chemistry
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：2016
• 期：22
• 页码：3649-3658
• 全文大小：1331K
• ISSN：1099-0682c

文摘

A series of new extended planar aromatic ligands based on an acridine core (dpac = dipyrido[3,2-a:2′,3′-c]acridine; dpacF₂ = 7,8-difluorodipyrido[3,2-a:2′,3′-c]acridine; dpacF₄ = 6,7,8,9-tetrafluorodipyrido[3,2-a:2′,3′-c]acridine) and their respective Ru^II complexes were synthesized and extensively studied. The photophysical and theoretical studies revealed that Ru-DPAC and Ru-DPACF₂ allow emission from a ³MLCT_phen/dpac excited state at 597 and 604 nm, respectively, whereas the lowest excited state for Ru-DPACF₄ shifts from a bright ³MLCT_phen/dpac state towards a poorly luminescent ³MLCT_dpac state (λ_em = 609 nm) owing to the formation of hydrogen bonds with water molecules in the excited state. These complexes exhibit up to sevenfold luminescence enhancement in the presence of complementary and mismatched DNA, demonstrating a strong binding to polynucleotides. The results emphasize the interest in Ru^II complexes bearing acridine derivatives as DNA interacting agents as a complement to the well-known phenazine-based derivatives.