Independent assessment of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) sample preparation quality: Effect of sample preparation on MALDI-MS of synthetic polymers

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• 作者：Pieter C. Kooijman ; Sander Kok and Maarten Honing
• 刊名：Rapid Communications in Mass Spectrometry
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：31
• 期：4
• 页码：362-370
• 全文大小：477K
• ISSN：1097-0231

文摘

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) provides detailed and in-depth information about the molecular characteristics of synthetic polymers. To obtain the most accurate results the sample preparation parameters should be chosen to suit the sample and the aim of the experiment. Because the underlying principles of MALDI are still not fully known, a priori determination of optimal sample preparation protocols is often not possible.