Differentiating tumor heterogeneity in formalin-fixed paraffin-embedded (FFPE) prostate adenocarcinoma tissues using principal component analysis of matrix-assisted laser desorption/ionization imaging mass spectral data
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- 作者：Irene Panderi ; Evgeny Yakirevich ; Silvana Papagerakis ; Lelia Noble ; Kara Lombardo and Dionysios Pantazatos
- 刊名：Rapid Communications in Mass Spectrometry
- 出版年：2017
- 出版时间：30 January 2017
- 年：2017
- 卷：31
- 期：2
- 页码：160-170
- 全文大小：1075K
- ISSN：1097-0231
文摘
Many patients with adenocarcinoma of the prostate present with advanced and metastatic cancer at the time of diagnosis. There is an urgent need to detect biomarkers that will improve the diagnosis and prognosis of this disease. Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) is playing a key role in cancer research and it can be useful to unravel the molecular profile of prostate cancer biopsies.