Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus)
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- 作者：Christopher Schrimpf ; Christoph Wrede ; Silke Glage ; Jan Hegermann ; Samantha Backhaus ; Rainer Blasczyk ; Hans-Gert Heuft and Thomas Mü ; ller
- 刊名：Transfusion
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：57
- 期：1
- 页码：60-69
- 全文大小：814K
- ISSN：1537-2995
文摘
Inherited and acquired marrow failure syndromes most commonly lead to defect in myeloid and/or neutrophil differentiation and/or function. Besides this, neutropenia induced by cancer-adjusted chemotherapy is a frequent clinical problem. In both cases, cell replacement therapy is a well-established, but due to necessity of donors limited and perilous procedure. Therefore, autologous cell replacement from patients' own marrow-derived cells lowers risk and bares new possibilities for therapy. Since the immune system of the marmoset monkey is known to show high similarity to humans, preclinical studies with these animals bare high hopes for immunologic research and cell replacement therapy.