Copper-Catalyzed Regioselective Sulfenylation of Indoles with Arylsulfonyl Chlorides
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- 作者：Prof. Dr. Zhimeng Wu ; Yan-Chun Li ; Wen-Zhang Ding ; Tao Zhu ; Shao-Zhong Liu ; Prof. Dr. Xuehong Ren and Prof. Dr. Liang-Hua Zou
- 刊名：Asian Journal of Organic Chemistry
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：5
- 期：5
- 页码：625-628
- 全文大小：451K
- ISSN：2193-5815
文摘
A copper-catalyzed regioselective sulfenylation of indoles and a pyrrolo[2,3-b]pyridine with arylsulfonyl chlorides has been developed by using low loadings of a copper catalyst and the cheap reductant PPh3. This method is effective for both N-protected and unprotected indoles, providing a series of structurally diverse indole thioethers in good to excellent yields with extremely high regioselectivity.