Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration

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• 作者：Kayla Belanger ; Tony M. Dinis ; Sami Taourirt ; Guillaume Vidal ; David L. Kaplan and Christopher Egles
• 关键词：bioengineering ; biomaterials ; peripheral nervous system ; polymers ; regenerative medicine
• 刊名：Macromolecular Bioscience
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：16
• 期：4
• 页码：472-481
• 全文大小：1290K
• ISSN：1616-5195

文摘

The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human tissue as a surrogate for the absence of the nerve. However, recent focus in the field has been on new polymer structures and specific biofunctionalization to achieve the goal of peripheral nerve regeneration by developing artificial nerve prostheses. This review presents various tested approaches as well their effectiveness for nerve regrowth and functional recovery.