Genetic Variants in the Vicinity of m>LGALS-3 m> Gene and m>LGALS m>-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study
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- 作者：Ana Djordjevic ; Maja Zivkovic ; Aleksandra Stankovic ; Ivan Zivotic ; Igor Koncar ; Lazar Davidovic ; Dragan Alavantic and Tamara Djuric
- 刊名：Journal of Clinical Laboratory Analysis
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：30
- 期：6
- 页码：1150-1157
- 全文大小：120K
- ISSN：1098-2825
文摘
Previous research has shown that there is an association between galectin-3 (gal-3) protein and cardiovascular pathology. The aim of this study was to investigate the effects of rs2274273 and rs17128183 on genetic susceptibility to advanced carotid atherosclerosis (CA) and its complications. The rs2274273 has been singled out as the lead SNP of the haplotype block containing m>LGALS-3 m> (gal-3 gene) associated with gal-3 circulating levels, while rs17128183 constitutes a potentially functional SNP of the same hap-block. We further sought to determine whether these genetic variants have an impact on the expression of m>LGALS-3 m>mRNA in human carotid atherosclerotic plaque tissue.