A novel prediction model for human papillomavirus-associated oropharyngeal squamous cell carcinoma using p16 and subcellular β-catenin expression
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- 作者：Guoqing Qian ; Zhongliang Hu ; Hong Xu ; Susan Mü ; ller ; Dongsheng Wang ; Hongzheng Zhang ; Sungjin Kim ; Zhengjia Chen ; Nabil F. Saba ; Dong M. Shin ; Andrew Y. Wang and Zhuo Georgia Chen
- 刊名：Journal of Oral Pathology & Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：45
- 期：6
- 页码：399-408
- 全文大小：731K
- ISSN：1600-0714
文摘
p16 overexpression is a highly sensitive yet moderately specific biomarker for predicting human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). Nuclear β-catenin translocation has been linked to HPV-positive OPSCC. However, whether the strategy of combining β-catenin with p16 can better predict HPV-associated OPSCC remains unknown.