New ent-Pimarane Diterpenes from the Roots of Aralia dumetorum
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- 作者：Chun-Tao Yang ; Shu-Qun Hou ; Kai Tian ; Qiu-Fen Hu ; Xiang-Zhong Huang and Zhi-Yong Jiang
- 关键词：Aralia dumetorum ; ent-Pimarane diterpenes ; Cytotoxic activity
- 刊名：Helvetica Chimica Acta
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：99
- 期：3
- 页码：220-224
- 全文大小：147K
- ISSN：1522-2675
文摘
Four new ent-pimarane diterpenes were isolated from the EtOH extract of Aralia dumetorum, together with three known compounds involving ent-pimar-8(14),15-dien-19-oic acid (5), ent-pimar-8(14),15-dien-19-ol (6), and ent-kaur-16-en-19-oic acid (7). By detailed analyses of the MS, IR, and NMR data, the structures of four new diterpenes were characterized as (5β,9β,10,13)-pimara-6,8(14),15-trien-18-oic acid (1), (5β,7β,9β,10,13)-7-methoxypimara-8(14),15-dien-18-oic acid (2), (5β,9β,10,13,14β)-14-methoxypimara-7,15-dien-18-oic acid (3), and (5β,10,13,14)-14-hydroxypimara-7,9(11),15-trien-18-oic acid (4). The cytotoxic activities of compounds 1 – 7 were assayed in vitro through MTT method.