Risk of multiple myeloma is associated with polymorphisms within telomerase genes and telomere length
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- 作者：Daniele Campa ; Alessandro Martino ; Judit Varkonyi ; Fabienne Lesueur ; Krzysztof Jamroziak ; Stefano Landi ; Artur Jurczyszyn ; Herlander Marques ; Vibeke Andersen ; Manuel Jurado ; Hermann Brenner ; Mario Petrini ; Ulla Vogel ; Ramó ; n Garcí ; a-Sanz ; Gabriele Buda ; Federica Gemignani ; Rafael Rí ; os ; Annette Juul Vangsted ; Charles Dumontet ; Joaquí ; n Martí ; nez-Ló ; pez ; Marí ; a José ; Moreno ; Anna Stępień ; Marzena Wątek ; Victor Moreno ; Aida Karina Dieffenbach ; Anna Maria Rossi ; Katja Butterbach ; Svend E. Hove Jacobsen ; Hartmut Goldschmidt ; Juan Sainz ; Jens Hillengass ; Enrico Orciuolo ; Marek Dudziński ; Niels Weinhold ; Rui Manuel Reis and Federico Canzian
- 关键词：multiple myeloma ; polymorphisms ; telomere length ; telomerase ; susceptibility
- 刊名：International Journal of Cancer
- 出版年：2015
- 出版时间：1 March 2015
- 年：2015
- 卷：136
- 期：5
- 页码：E351-E358
- 全文大小：189K
- ISSN：1097-0215
文摘
Compelling biological and epidemiological evidences point to a key role of genetic variants of the TERT and TERC genes in cancer development. We analyzed the genetic variability of these two gene regions using samples of 2,267 multiple myeloma (MM) cases and 2,796 healthy controls. We found that a TERT variant, rs2242652, is associated with reduced MM susceptibility (OR = 0.81; 95% CI: 0.72–0.92; p = 0.001). In addition we measured the leukocyte telomere length (LTL) in a subgroup of 140 cases who were chemotherapy-free at the time of blood donation and 468 controls, and found that MM patients had longer telomeres compared to controls (OR = 1.19; 95% CI: 0.63–2.24; ptrend = 0.01 comparing the quartile with the longest LTL versus the shortest LTL). Our data suggest the hypothesis of decreased disease risk by genetic variants that reduce the efficiency of the telomerase complex. This reduced efficiency leads to shorter telomere ends, which in turn may also be a marker of decreased MM risk.