Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage
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- 作者：Xiaolei Cai ; Aishwarya Bandla ; Duo Mao ; Guangxue Feng ; Wei Qin ; Lun-De Liao ; Nitish Thakor ; Ben Zhong Tang and Bin Liu
- 刊名：Advanced Materials
- 出版年：2016
- 出版时间：October 19, 2016
- 年：2016
- 卷：28
- 期：39
- 页码：8760-8765
- 全文大小：1174K
- ISSN：1521-4095
文摘
Detection of damage to the blood–brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation-induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.