Contactless decontamination of hair samples: cannabinoids

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• 作者：Jos&eacute ; Restolho ; Má ; rio Barroso ; Benilde Saramago ; Má ; rio Dias and Carlos A.M. Afonso
• 刊名：Drug Testing and Analysis
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：9
• 期：2
• 页码：282-288
• 全文大小：378K
• ISSN：1942-7611

文摘

Room temperature ionic liquids (ILs) have already been shown to provide efficient extraction media for several systems, and to capture volatile compounds, namely opiates. In this work, a novel, contactless, artefact-free extraction procedure for the removal of Δ⁹-tetrahrydrocannabinol (THC) from the surface of human hair is presented. To prepare m>in vitrom> cannabinoids-contaminated hair, samples were flushed with hashish smoke for 7 h. The decontamination experiments were carried at 100 °C for 24 h, according to the procedure previously described. Fifty-three ILs were screened and presented decontamination efficiencies ranging from 0 to 96 %. Although the majority of the ILs presented efficiencies above 90%, the 1-ethanol-3-methyl tetrafluoroborate (96%) was chosen for further process optimization. The Design of Experiments results demonstrated that all studied variables were significant for the process and the obtained optimum conditions were: 100 °C, 13 h and 175 mg of IL. In the work of Perrotin-Brunel m>et alm>. (m>Jm>. m>Molm>. m>Structm>. 2011, m>987m>, 67), it is demonstrated that, at 100 °C, full conversion of tetrahydrocannabinolic acid (THCA) into THC is obtained after 60 min. Since our decontamination takes place over 13 h at 100 °C, full conversion of THCA into THC is expected. Additionally, our method was compared with the method proposed by Cairns m>et alm>. (m>Forensicm> m>Scim>. m>Intm>. 2004, m>145m>, m>97m>), through the analysis of 15 m>in vitrom> contaminated hair samples. The results demonstrated that with our method a mean extraction efficiency of 11 % higher was obtained. Copyright