Increased microvascular permeability in mice lacking Epac1 (Rapgef3)

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• 作者：R. K. Kopperud ; C. Brekke Rygh ; T. V. Karlsen ; C. Krakstad ; R. Kleppe ; E. A. Hoivik ; M. Bakke ; O. Tenstad ; F. Selheim ; Å ; . Lid&eacute ; n ; L. Madsen ; T. Pavlin ; T. Taxt ; K. Kristiansen ; F.-R. E. Curry ; R. K. Reed and S. O. D&oslash ; skeland
• 刊名：Acta Physiologica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：219
• 期：2
• 页码：441-452
• 全文大小：1002K
• ISSN：1748-1716

文摘

Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine nucleotide exchange factor 3 and 4 (Epac1 and Epac2) for in vivo control of microvascular macromolecule permeability under basal conditions.