Both enantiomers of 2-aminotetralines and 3-aminochromanes a
re easily accessible via asymmet
ric hyd
rogenation by simply switching f
rom Rh to I
r. The chi
ral info
rmation is p
rovided by a phosphite-
thioethe
r ligand, with a simple a
rchitectu
re, de
rived f
rom
d-mannitol. This pictu
re illust
rates how the chi
ral pool can be used to synthesize these phosphite-
thioethe
r ligands that in combination with eithe
r Rh- o
r I
r-catalyst p
recu
rso
rs allow the efficient enantioswitchable hyd
rogenation of cyclic β-enamides. Mo
re info
rmation can be found in the Full Pape
r by O. P&ag
rave;mies and M. Di&
eacute;guez et al. on
ref="https://doi.org/10.1002/chem.201604483" rel="references:https://doi.org/10.1002/chem.201604483">page 813 ff.