A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes

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• 作者：Frances Kindt ; Elke Hammer ; Stefan Kemnitz ; Antje Blumenthal ; Paul Klemm ; Rabea Schlü ; ter ; Susan E Quaggin ; Jens van den Brandt ; Georg Fuellen ; Uwe V&ouml ; lker ; Karlhans Endlich and Nicole Endlich
• 刊名：British Journal of Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：174
• 期：2
• 页码：163-176
• 全文大小：1861K
• ISSN：1476-5381

文摘

Therapeutic options for treating glomerulopathies, the main cause of chronic kidney disease, are limited. Podocyte dedifferentiation is a major event in the pathogenesis of glomerulopathies. The goal of the present study was, therefore, to develop an assay to monitor podocyte differentiation suitable for compound screening.