Pancreatic polypeptide stimulates mouse gastric motor activity through peripheral neural mechanisms
详细信息 查看全文
- 作者：A. Amato ; S. Baldassano ; G. F. Caldara and F. Mulè
- 刊名：Neurogastroenterology & Motility
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：29
- 期：1
- 全文大小：635K
- ISSN：1365-2982
文摘
Pancreatic polypeptide (PP) is supposed to be one of the major endogenous agonists of the neuropeptide Y4 receptor. Pancreatic polypeptide can influence gastrointestinal motility, acting mainly through vagal mechanisms, but whether PP acts directly on the stomach has not been explored yet. The aims of this study were to investigate the effects of PP on mouse gastric emptying, on spontaneous tone of whole stomach in vitro and to examine the mechanism of action.