How Does Aging Affect Presentation and Management of Biliary Stones?

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• 作者：Kuang-Chun Hu ; Cheng-Hsin Chu ; Horng-Yuan Wang ; Wen-Hsiung Chang ; Shee-Chan Lin ; Chuan-Chuan Liu ; Wei-Chih Liao ; Chun-Jen Liu ; Ming-Shiang Wu and Shou-Chuan Shih
• 刊名：Journal of the American Geriatrics Society
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：64
• 期：11
• 页码：2330-2335
• 全文大小：163K
• ISSN：1532-5415

文摘

Common bile duct (CBD) stones are common in elderly adults, but the effect of aging on the presentation of CBD stones remains to be evaluated. Recent studies have demonstrated that the clinical presentation of CBD stones may vary with age. Younger adults may present with classical biliary colic symptoms, whereas elderly adults may have no unapparent clinical features. Younger adults with CBD stones were significantly more likely to have abnormal liver function tests than those without. The sensitivity and accuracy of transabdominal ultrasound scans in screening for CBD stones increases with age. Antibiotic agents should be promptly administered to individuals with CBD stones complicated by cholangitis, but the effects of pharmacotherapy on renal function should be considered in elderly adults. Endoscopic retrograde cholangiopancreatography (ERCP) is considered to be first-line treatment for CBD stones, and endoscopic biliary sphincterotomy (EST) or endoscopic papillary balloon dilation (EPBD) along with ERCP is an adequate biliary drainage method in individuals with CBD stones. EPBD has a lower bleeding risk but higher post-ERCP risk of pancreatitis than EST. Longer-duration (>1 minute) EPBD may be preferred over EST because it is associated with a comparable risk of pancreatitis but a lower rate of overall complications, although recurrent cholangitis or unfavorable outcomes will increase during CBD dilation or in the presence of residual CBD stones.