Changes in Lymphangiogenesis and Vascular Endothelial Growth Factor Expression by Neo-Adjuvant Hormonal Therapy in Prostate Cancer Patients

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• 作者：Akihiro Asai ; Yasuyoshi Miyata ; Tomohiro Matsuo ; Yohei Shida ; Tomoaki Hakariya ; Kojiro Ohba and Hideki Sakai
• 刊名：The Prostate
• 出版年：2017
• 出版时间：February 15, 2017
• 年：2017
• 卷：77
• 期：3
• 页码：255-262
• 全文大小：882K
• ISSN：1097-0045

文摘

The anti-cancer mechanism of neo-adjuvant hormonal therapy (NHT) is not well understood. Lymphangiogenesis plays an important role in cancer progression and is regulated by a complex mechanism that includes vascular endothelial growth factor (VEGF) signaling. However, there is little information regarding relationship between lymphangiogenesis and androgen deprivation. The aim of this study was to clarify changes in lymphangiogenesis and VEGF expression induced by androgen deprivation in prostate cancer in vivo and in vitro.