Molecular epidemiology of Crimean-Congo hemorrhagic fever in Bulgaria—An update

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• 作者：Anna Papa ; Styliani Pappa ; Elitsa Panayotova ; Elpida Papadopoulou and Iva Christova
• 关键词：Crimean&ndash ; Congo hemorrhagic fever ; Bulgaria ; molecular epidemiology
• 刊名：Journal of Medical Virology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：88
• 期：5
• 页码：769-773
• 全文大小：421K
• ISSN：1096-9071

文摘

Crimean–Congo hemorrhagic fever (CCHF) is endemic in Bulgaria. During 2013–2014, 11 confirmed CCHF cases have been reported in the country (seven in 2013 and four in 2014). The present study provides the CCHF molecular epidemiology in Bulgaria based on all currently available S, M, and L RNA segment nucleotide sequences spanning the years 1978–2014. A relatively low genetic difference (0–6%, the maximum seen in the M RNA segment) was seen among the CCHFV sequences suggesting that a slow evolving CCHFV strain belonging to “Europe 1” clade is present in Bulgaria. Although the virus emerged in new foci during the recent years, it is more active in the established endemic foci which seem to offer the most suitable ecosystem and environment. Understanding the CCHF epidemiology and virus evolution is the basis for public health programs and vaccine design. J. Med. Virol. 88:769–773, 2016.