Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis
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- 作者：Llipsy Santiago ; Cheikh Menaa ; Maykel Arias ; Praxedis Martin ; Paula Jaime-Sá ; nchez ; Sunil Metkar ; Laura Comas ; Nadina Erill ; Victor Gonzalez-Rumayor ; Erica Esser ; Eva M. Galvez ; Sri Raja ; Markus M. Simon ; Stuart M. Sprague ; Cem Gabay ; Luis Martinez-Lostao ; Julian Pardo and Christopher J. Froelich
- 刊名：Arthritis & Rheumatism
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：69
- 期：2
- 页码：320-334
- 全文大小：835K
- ISSN：1529-0131
文摘
Granzyme A (GzmA) levels are elevated in the plasma and synovium of patients with rheumatoid arthritis (RA), suggesting involvement of this protease in the pathogenesis of the disease. GzmA contributes to sepsis by regulating the production of proinflammatory cytokines. The purpose of this study was to evaluate the contribution of GzmA to the pathogenesis of RA in vivo and to examine the possibility that GzmA acting via tumor necrosis factor (TNF) stimulates osteoclastogenesis.