Impact of Isotope Dilution Mass Spectrometry (IDMS) Standardization on Carboplatin Dose and Adverse Events

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• 作者：Justin Lawson ; Jeffrey M. Switchenko ; Trevor McKibbin and R. Donald Harvey
• 刊名：Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：36
• 期：6
• 页码：617-622
• 全文大小：177K
• ISSN：1875-9114

文摘

When using area under the concentration–time curve–based strategies for dosing carboplatin, accurate estimation of glomerular filtration rate is required for determining dose. Commonly, the Cockcroft–Gault equation is used, which is dependent on measurement of serum creatinine (SCr). Because analysis of SCr changed to an isotope dilution mass spectrometry (IDMS) standard, we sought to determine the impact of this assay change on carboplatin dosing and related toxicity.