Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice
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- 作者：Fahrettin Haczeyni ; Laurence Poekes ; Hans Wang ; Auvro R. Mridha ; Vanessa Barn ; W. Geoffrey Haigh ; George N. Ioannou ; Matthew M. Yeh ; Isabelle A. Leclercq ; Narcissus C. Teoh and Geoffrey C. Farrell
- 刊名：Obesity
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：25
- 期：1
- 页码：155-165
- 全文大小：1237K
- ISSN：1930-739X
文摘
Nonalcoholic steatohepatitis (NASH) is the outcome of interactions between overnutrition, energy metabolism, and adipose function. Obeticholic acid (OCA) improves steatosis in patients but for unknown reasons does not resolve NASH pathology. This study therefore investigated OCA effects in Wt mice, which develop obesity with atherogenic dietary feeding, and appetite-dysregulated, Alms1 mutant foz/foz mice fed the same diet, which develop metabolic obesity and diabetes.