A Mild TEMPO-Catalyzed Aerobic Oxidative Conversion of Aldehydes into Nitriles

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• 作者：Chaojie Fang ; Meichao Li ; Xinquan Hu ; Weimin Mo ; Baoxiang Hu ; Nan Sun ; Liqun Jin and Zhenlu Shen
• 关键词：aldehydes ; hexamethyldisilazane (HMDS) ; nitriles ; oxidation ; oxygen ; 2 ; 2 ; 6 ; 6-tetramethylpiperidine 1-oxyl (TEMPO)
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：March 31, 2016
• 年：2016
• 卷：358
• 期：7
• 页码：1157-1163
• 全文大小：526K
• ISSN：1615-4169

文摘

An efficient method to prepare nitriles from aldehydes using hexamethyldisilazane (HMDS) as the nitrogen source has been developed. The reactions were performed with 2,2,6,6-tetramethylpiperidine l-oxyl (TEMPO) as the catalyst, NaNO₂ or TBN as the co-catalyst, and molecular oxygen as the terminal oxidant under mild conditions. A variety of aromatic, heteroaromatic, aliphatic and allylic aldehydes could be converted into their corresponding nitriles in good to excellent yields.